INSERM U970, Paris Cardiovascular Research Centre, Paris, F-75015, France


Short biography
After his PhD in the lab headed by Philippe Sansonetti in the Institut Pasteur, G. Dumenil joined the lab headed by Ralph Isberg at Tufts University as a postdoctoral fellow. G. Dumenil then obtained a position at INSERM to join the lab headed by Xavier Nassif to study infections caused by the extracellular pathogen Neisseria meningitidis. After obtaining a prestigious starting grant from INSERM (ATIP-Avenir) G. Dumenil is now directeur de recherche in the Paris Center for Cardiovascular Research (PARCC) located in Paris. The main focus of his research is the study of the interaction of pathogenic bacteria with blood vessels during septicemia and meningitis.

Title of the lecture
Vascular colonization by Neisseria meningitidis

Bacterial infection of human vasculature can lead to unregulated systemic activation of coagulation and innate immunity and rapidly becomes life threatening. Neisseria meningitidis is a vascular pathogen that causes fatal septic shock and meningitis. Post-mortem histological analysis of tissues from individuals infected with N. meningitidis show large bacterial aggregates in close association with the vascular wall of small vessels. The ability of this bacterium to colonize blood vessel endothelium is likely to impact its capacity to both multiply in the blood stream and reach the brain. This process is referred to as vascular colonization. Recent work from our group exploring the early steps in N. meningitidis vascular colonization will be reported, from attachment to proliferation and dissemination, focusing on the bacterial–host interaction.